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PostPosted: Wed Jun 13, 2018 1:15 am 
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Joined: Tue Jan 31, 2012 11:05 am
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So much shit news every day would be nice to have a place where you can read some good news. Or anything that you read online that fascinated you for some reason.


Prostate cancer saliva test could identify men more likely to contract killer disease

A saliva swab could help quickly identify the men most at risk of prostate cancer after UK researchers tracked down a host of genetic changes that make the disease up to four times more likely.

The spit test is currently undergoing trials across three London GP surgeries, initially involving 300 men, to see if the DNA changes they have identified reliably map to actual cancer cases.

Prostate cancer is the most common form of cancer among men in developed countries. As much as 50 per cent of the disease risk is thought to be inherited through genes – rather than caused by diet or exercise.
The rise in prostate cancer deaths is not down to gender bias
By studying the genetic information of 140,000 men, including 80,000 who had prostate cancer, researchers at the Institute of Cancer Research (ICR) in London and Cambridge University identified 63 new genetic changes that increase this risk.

Added to roughly 100 genes that were already known to be linked to the disease the research, published today in the journal Nature Genetics, is big enough to move from the lab to the clinic.

Roughly one in eight men in the UK will be diagnosed with prostate cancer in their lifetime. Men with most of these genetic changes have closer to a 50/50 chance.

Identifying these at-risk men would allow them to be prioritised for more regular screening to help catch the cancer earlier, or to make lifestyle changes to minimise their risk.

It could also prevent men at lower risk from having invasive biopsies unnecessarily, which could save NHS time and money, and lower complications for patients.

“We have uncovered vital new information about the genetic factors that can predispose someone to prostate cancer, and, crucially, we have shown that information from more than 150 genetic variants can now be combined to provide a readout of a man’s inherited risk of prostate cancer,” said Professor Ros Eeles, professor of oncogenetics at the ICR.

“The next step is to see if we can use that information to help prevent the disease,” she added. This is where the GP trials come in and they are expected to be expanded to include 5,000 men next year.

Prostate cancer recently overtook breast cancer as the UK’s third biggest killer and late diagnosis remains a major obstacle to effective treatment.

Dr Iain Frame, director of research at Prostate Cancer UK, said: “This new research could help men to understand their individual genetic risk of prostate cancer, which could prompt them to speak to their GP about the disease.

“Given that one in eight men will be diagnosed with prostate cancer in their lifetime, we urgently need more accurate diagnostic tests which are suitable for use in a nationwide screening programme.” ... 93926.html

And found this fascinating

Water Exists as Two Different Liquids
Scientists at Stockholm University have discovered two phases of liquid water with large differences in structure and density. The results are based on experimental studies using X-rays, which are now published in PNAS.

We normally consider liquid water as disordered with the molecules rearranging on a short time scale around some average structure. Now, however, scientists at Stockholm University have discovered two phases of the liquid with large differences in structure and density. The results are based on experimental studies using X-rays, which are now published in Proceedings of the National Academy of Science (US).

Most of us know that water is essential for our existence on planet Earth. It is less well-known that water has many strange or anomalous properties and behaves very differently from all other liquids. Some examples are the melting point, the density, the heat capacity, and all-in-all there are more than 70 properties of water that differ from most liquids. These anomalous properties of water are a prerequisite for life as we know it.

“The new remarkable property is that we find that water can exist as two different liquids at low temperatures where ice crystallization is slow”, says Anders Nilsson, professor in Chemical Physics at Stockholm University. The breakthrough in the understanding of water has been possible through a combination of studies using X-rays at Argonne National Laboratory near Chicago, where the two different structures were evidenced and at the large X-ray laboratory DESY in Hamburg where the dynamics could be investigated and demonstrated that the two phases indeed both were liquid phases. Water can thus exist as two different liquids.

“It is very exciting to be able to use X-rays to determine the relative positions between the molecules at different times”, says Fivos Perakis, postdoc at Stockholm University with a background in ultrafast optical spectroscopy. “We have in particular been able to follow the transformation of the sample at low temperatures between the two phases and demonstrated that there is diffusion as is typical for liquids”.

When we think of ice it is most often as an ordered, crystalline phase that you get out of the ice box, but the most common form of ice in our planetary system is amorphous, that is disordered, and there are two forms of amorphous ice with low and high density. The two forms can interconvert and there have been speculations that they can be related to low- and high-density forms of liquid water. To experimentally investigate this hypothesis has been a great challenge that the Stockholm group has now overcome.

“I have studied amorphous ices for a long time with the goal to determine whether they can be considered a glassy state representing a frozen liquid”, says Katrin Amann-Winkel, researcher in Chemical Physics at Stockholm University. “It is a dream come true to follow in such detail how a glassy state of water transforms into a viscous liquid which almost immediately transforms to a different, even more viscous, liquid of much lower density”.

“The possibility to make new discoveries in water is totally fascinating and a great inspiration for my further studies”, says Daniel Mariedahl, PhD student in Chemical Physics at Stockholm University. “It is particularly exciting that the new information has been provided by X-rays since the pioneer of X-ray radiation, Wolfgang Röntgen, himself speculated that water can exist in two different forms and that the interplay between them could give rise to its strange properties”.

“The new results give very strong support to a picture where water at room temperature can’t decide in which of the two forms it should be, high or low density, which results in local fluctuations between the two”, says Lars G.M. Pettersson, professor in Theoretical Chemical Physics at Stockholm University. “In a nutshell: Water is not a complicated liquid, but two simple liquids with a complicated relationship.”

These new results not only create an overall understanding of water at different temperatures and pressures, but also how water is affected by salts and biomolecules important for life. In addition, the increased understanding of water can lead to new insights on how to purify and desalinate water in the future. This will be one of the main challenges to humanity in view of the global climate change.

These studies were led by Stockholm University and involve a collaboration including the KTH Royal Institute of Technology in Stockholm, DESY in Hamburg, University of Innsbruck, Argonne National Laboratory in Chicago and SLAC National Accelerator Laboratory in California. The other participants from Stockholm University involved in the study are Harshad Pathak, Alexander Späh, Filippo Cavalca and Daniel Schlesinger. Experiments were conducted at APS BL 6-ID-D at Argonne National Laboratory and PETRA III BL P10 at DESY. ... s-1.338715

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