Malaria & Covid-19

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Fat Albert
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Re: Malaria & Covid-19

Post by Fat Albert »

Dr. Vladimir Zelenko has now treated 699 coronavirus patients with 100% success using Hydroxychloroquine Sulfate, Zinc and Z-Pak
Dr. Zelenko provides updates after he successfully treated 699 COVID-19 patients in New York. In an exclusive interview with former New York Mayor, Rudy Giuliani, Dr. Vladmir Zelenko shares the results of his latest study, which showed that out of his 699 patients treated, zero patients died, zero patients intubated, and four hospitalizations.
French researchers completed additional study on 80 patients, results show a combination of Hydroxychloroquine and Azithromycin to be effective in treating COVID-19
We need an effective treatment to cure COVID-19 patients and to decrease the virus carriage duration. In 80 in-patients receiving a combination of hydroxychloroquine and azithromycin we noted a clinical improvement in all but one 86 year-old patient who died, and one 74 yearold patient still in intensive care unit. A rapid fall of nasopharyngeal viral load tested by qPCR was noted, with 83% negative at Day7, and 93% at Day8. Virus cultures from patient respiratory samples were negative in 97.5% patients at Day5. This allowed patients to rapidly be discharge from highly contagious wards with a mean length of stay of five days. We believe other teams should urgently evaluate this cost-effective therapeutic strategy, to both avoid the spread of the disease and treat patients as soon as possible before severe respiratory irreversible complications take hold.
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Re: Malaria & Covid-19

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msp. wrote:How many of the population in places that have Malaria are on these drugs, most of the population cannot afford to be in anti-malaria drugs, it is mainly westerners going to those locations that take the drugs.

The protection that most have is sleeping under a net, (could it be this that is providing the protection).
Don't tell Trump.
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Fat Albert
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Re: Malaria & Covid-19

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In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) first broke out in Wuhan (China) and subsequently spread worldwide. Chloroquine has been sporadically used in treating SARS-CoV-2 infection. Hydroxychloroquine shares the same mechanism of action as chloroquine, but its more tolerable safety profile makes it the preferred drug to treat malaria and autoimmune conditions. We propose that the immunomodulatory effect of hydroxychloroquine also may be useful in controlling the cytokine storm that occurs late-phase in critically ill SARS-CoV-2 infected patients. Currently, there is no evidence to support the use of hydroxychloroquine in SARS-CoV-2 infection.
Yes, I noted the last sentence, which refers to evidence 'in vitro' (laboratory), the paper does not refer to efficacy on patients.

Surely there is now more than enough practical evidence, with more published every day, that Hydroxychloroquin though not a panacea, is of net benefit to Covid-19 patients.
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JM2K6
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Re: Malaria & Covid-19

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Fat Albert wrote:Dr. Vladimir Zelenko has now treated 699 coronavirus patients with 100% success using Hydroxychloroquine Sulfate, Zinc and Z-Pak
Dr. Zelenko provides updates after he successfully treated 699 COVID-19 patients in New York. In an exclusive interview with former New York Mayor, Rudy Giuliani, Dr. Vladmir Zelenko shares the results of his latest study, which showed that out of his 699 patients treated, zero patients died, zero patients intubated, and four hospitalizations.
A massive pinch of salt required.

https://www.snopes.com/fact-check/zelen ... -patients/

"Zelenko’s claims, however, rest solely on taking him at his word: He has published no data, described no study design, and reported no analysis."

French researchers completed additional study on 80 patients, results show a combination of Hydroxychloroquine and Azithromycin to be effective in treating COVID-19
We need an effective treatment to cure COVID-19 patients and to decrease the virus carriage duration. In 80 in-patients receiving a combination of hydroxychloroquine and azithromycin we noted a clinical improvement in all but one 86 year-old patient who died, and one 74 yearold patient still in intensive care unit. A rapid fall of nasopharyngeal viral load tested by qPCR was noted, with 83% negative at Day7, and 93% at Day8. Virus cultures from patient respiratory samples were negative in 97.5% patients at Day5. This allowed patients to rapidly be discharge from highly contagious wards with a mean length of stay of five days. We believe other teams should urgently evaluate this cost-effective therapeutic strategy, to both avoid the spread of the disease and treat patients as soon as possible before severe respiratory irreversible complications take hold.
This is much more promising :thumbup: and is one of the main reasons why this treatment is being talked about (though with this caveat https://www.france24.com/en/20200331-fr ... treatments ). However, this study has no control group, which makes it a very hard sell indeed. I thoroughly recommend reading the comments here: https://pubpeer.com/publications/16FA31 ... E929C86BB0

Note that their previous publications were really rushed and they never responded to peer review & criticism, so again, pinch of salt.

Would be brilliant if it was true, though (and that easy).


More reading on that study:

https://sciencebasedmedicine.org/hydrox ... -covid-19/
https://blogs.sciencemag.org/pipeline/a ... -dr-raoult
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Re: Malaria & Covid-19

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Derwyn wrote:
Fat Albert wrote:
Both chloroquine and hydroxychloroquine appear to be zinc ionophores. It is the zinc that interferes with a virus. The Corona Virus is an RNA virus. When a virus goes into the cytosol, the ribosomes which read the code of the mRNA can’t tell the difference between the virus RNA and cellular RNA. So, as the ribosomes read the viral RNA they make an RNA dependent RNA polymerase (Replicase) that replicates the viral RNA. It’s a nasty son of a bitch. Zn(2+) will interfere with Replicase. However, zinc doesn’t readily transport inside the cell but, a zinc ionophore helps zinc move inside the cell.
Just what I was going to say.
I read Quercetin is a zinc ionophore.
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Fat Albert
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Re: Malaria & Covid-19

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JM2K6 wrote:However, this study has no control group, which makes it a very hard sell indeed.
I can just imagine the response of the relatives of those desperately ill patients who are told that they are going to be part of a double blind trial where some will receive a placebo...

Again, I'm glad I'm not a doctor/administrator making those decisions...
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Re: Malaria & Covid-19

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Fat Albert wrote:
JM2K6 wrote:However, this study has no control group, which makes it a very hard sell indeed.
I can just imagine the response of the relatives of those desperately ill patients who are told that they are going to be part of a double blind trial where some will receive a placebo...

Again, I'm glad I'm not a doctor/administrator making those decisions...
Sure - but science is science. It's also not obvious they were desperately ill; only 15% had a fever, four of them didn't have any symptoms at all (!?!).

The more I read about that study, the worse it gets. Right from the start (calling it an observational study when it clearly isn't, seemingly to avoid certain restrictions) there's red flags and the responses I've posted seem to be pretty clear that this work is incredibly dubious.

We need good science now more than ever. It's not clear that this is good science.
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Re: Malaria & Covid-19

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Fat Albert wrote:Dr. Vladimir Zelenko has now treated 699 coronavirus patients with 100% success using Hydroxychloroquine Sulfate, Zinc and Z-Pak
Dr. Zelenko provides updates after he successfully treated 699 COVID-19 patients in New York. In an exclusive interview with former New York Mayor, Rudy Giuliani, Dr. Vladmir Zelenko shares the results of his latest study, which showed that out of his 699 patients treated, zero patients died, zero patients intubated, and four hospitalizations.
Why am I not surprised that Mad Rudy is balls deep in this.

A proper trial at my place of work.
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Re: Malaria & Covid-19

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puku wrote:
Fat Albert wrote:Dr. Vladimir Zelenko has now treated 699 coronavirus patients with 100% success using Hydroxychloroquine Sulfate, Zinc and Z-Pak
Dr. Zelenko provides updates after he successfully treated 699 COVID-19 patients in New York. In an exclusive interview with former New York Mayor, Rudy Giuliani, Dr. Vladmir Zelenko shares the results of his latest study, which showed that out of his 699 patients treated, zero patients died, zero patients intubated, and four hospitalizations.
Why am I not surprised that Mad Rudy is balls deep in this.

A proper trial at my place of work.
Good stuff. Sounds as though FA knows a hospital in the UK where they are possibly running trials too.
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Re: Malaria & Covid-19

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Saw on twitter that some tweets highlighting successful uses of chloroquine were being removed x(
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Re: Malaria & Covid-19

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Lemoentjie wrote:Saw on twitter that some tweets highlighting successful uses of chloroquine were being removed x(
Probably regarded as fake/dangerous news.
Enough people died in Iran for stuff like that to be taken down.
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Re: Malaria & Covid-19

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Lemoentjie wrote:Saw on twitter that some tweets highlighting successful uses of chloroquine were being removed x(
Twitter and Facebook are pulling down stories regarding any treatment not on the WHO list. So far Donald's comments are staying up but that won't last
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Re: Malaria & Covid-19

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Rugby2023 wrote:
Derwyn wrote:
Fat Albert wrote:
Both chloroquine and hydroxychloroquine appear to be zinc ionophores. It is the zinc that interferes with a virus. The Corona Virus is an RNA virus. When a virus goes into the cytosol, the ribosomes which read the code of the mRNA can’t tell the difference between the virus RNA and cellular RNA. So, as the ribosomes read the viral RNA they make an RNA dependent RNA polymerase (Replicase) that replicates the viral RNA. It’s a nasty son of a bitch. Zn(2+) will interfere with Replicase. However, zinc doesn’t readily transport inside the cell but, a zinc ionophore helps zinc move inside the cell.
Just what I was going to say.
I read Quercetin is a zinc ionophore.


This from the internet, dates back to 2010. Apparently peer reviewed.

https://journals.plos.org/plospathogens ... at.1001176
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Re: Malaria & Covid-19

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Hydroxychloroquine and azithromycin are both QT prolongation drugs meaning both, especially if used in combination, can cause ventricular arrhythmia and may very well kill an elderly person with existing VA. Both are also associated with liver failure in the hepatically impaired.
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Re: Malaria & Covid-19

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Hellraiser wrote:Hydroxychloroquine and azithromycin are both QT prolongation drugs meaning both, especially if used in combination, can cause ventricular arrhythmia and may very well kill an elderly person with existing VA. Both are also associated with liver failure in the hepatically impaired.
Yeah. But Trump has a hunch.
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Re: Malaria & Covid-19

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Hellraiser wrote:Hydroxychloroquine and azithromycin are both QT prolongation drugs meaning both, especially if used in combination, can cause ventricular arrhythmia and may very well kill an elderly person with existing VA. Both are also associated with liver failure in the hepatically impaired.
known side effects, and why zelenko starts with low doses.

when the odds of dying are worse without treatment you'll take the chance.
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Re: Malaria & Covid-19

Post by JM2K6 »

https://twitter.com/DrEricDing/status/1 ... 3468306433
Chloroquine #COVID19 trial discontinued in Sweden cuz of severe side effects- seizure and vision problems in patients. (
📍 Early clinical trial termination is strictly guided by data safety monitoring committees- stoppages are rare & big deal bad signs)
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Re: Malaria & Covid-19

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Huge study on Hydroxychloroquine in the lancet
Findings
96 032 patients (mean age 53·8 years, 46·3% women) with COVID-19 were hospitalised during the study period and met the inclusion criteria. Of these, 14 888 patients were in the treatment groups (1868 received chloroquine, 3783 received chloroquine with a macrolide, 3016 received hydroxychloroquine, and 6221 received hydroxychloroquine with a macrolide) and 81 144 patients were in the control group. 10 698 (11·1%) patients died in hospital. After controlling for multiple confounding factors (age, sex, race or ethnicity, body-mass index, underlying cardiovascular disease and its risk factors, diabetes, underlying lung disease, smoking, immunosuppressed condition, and baseline disease severity), when compared with mortality in the control group (9·3%), hydroxychloroquine (18·0%; hazard ratio 1·335, 95% CI 1·223–1·457), hydroxychloroquine with a macrolide (23·8%; 1·447, 1·368–1·531), chloroquine (16·4%; 1·365, 1·218–1·531), and chloroquine with a macrolide (22·2%; 1·368, 1·273–1·469) were each independently associated with an increased risk of in-hospital mortality. Compared with the control group (0·3%), hydroxychloroquine (6·1%; 2·369, 1·935–2·900), hydroxychloroquine with a macrolide (8·1%; 5·106, 4·106–5·983), chloroquine (4·3%; 3·561, 2·760–4·596), and chloroquine with a macrolide (6·5%; 4·011, 3·344–4·812) were independently associated with an increased risk of de-novo ventricular arrhythmia during hospitalisation.
Interpretation
We were unable to confirm a benefit of hydroxychloroquine or chloroquine, when used alone or with a macrolide, on in-hospital outcomes for COVID-19. Each of these drug regimens was associated with decreased in-hospital survival and an increased frequency of ventricular arrhythmias when used for treatment of COVID-19.
So: It doesn't help, and it increases your chance of dying in hospital
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Re: Malaria & Covid-19

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Yeah but it's acts with covid-19 like garlic does with vampires
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Re: Malaria & Covid-19

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. But he still has a hunch, and 100m doses. Got to find s market for that stuff.

Trump's genuine hydroxysnakeoiline cures aids, covid, cancer and erectile dysfunction.
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Re: Malaria & Covid-19

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For our FA

https://www.thelancet.com/journals/lanc ... 6/fulltext
Research in context
Evidence before this study
We searched MEDLINE (via PubMed) for articles published up to April 21, 2020, using the key words “novel coronavirus”, “2019-nCoV”, “COVID-19”, “SARS-CoV-2”, “therapy”, “hydroxychloroquine”, “chloroquine”, and “macrolide”. Moreover, we screened preprint servers, such as Medrxiv, for relevant articles and consulted the web pages of organisations such as the US National Institutes of Health and WHO. Hydroxychloroquine and chloroquine (used with or without a macrolide) are widely advocated for treatment of COVID-19 based on in-vitro evidence of an antiviral effect against severe acute respiratory syndrome coronavirus 2. Their use is based on small uncontrolled studies and in the absence of evidence from randomised controlled trials. Concerns have been raised that these drugs or their combination with macrolides could result in electrical instability and predispose patients to ventricular arrhythmias. Whether these drugs improve outcomes or are associated with harm in COVID-19 remains unknown.
Added value of this study
In the absence of reported randomised trials, there is an urgent need to evaluate real-world evidence related to outcomes with the use of hydroxychloroquine or chloroquine (used with or without macrolides) in COVID-19. Using an international, observational registry across six continents, we assessed 96 032 patients with COVID-19, of whom 14 888 were treated with hydroxychloroquine, chloroquine, or their combination with a macrolide. After controlling for age, sex, race or ethnicity, underlying comorbidities, and disease severity at baseline, the use of all four regimens was associated with an increased hazard for de-novo ventricular arrythmia and death in hospital. This study provides real-world evidence on the use of these therapeutic regimens by including a large number of patients from across the world. Thus, to our knowledge, these findings provide the most comprehensive evidence of the use of hydroxychloroquine and chloroquine (with or without a macrolide) for treatment of COVID-19.
Implications of all the available evidence
We found no evidence of benefit of hydroxychloroquine or chloroquine when used either alone or with a macrolide. Previous evidence was derived from either small anecdotal studies or inconclusive small randomised trials. Our study included a large number of patients across multiple geographic regions and provides the most robust real-world evidence to date on the usefulness of these treatment regimens. Although observational studies cannot fully account for unmeasured confounding factors, our findings suggest not only an absence of therapeutic benefit but also potential harm with the use of hydroxychloroquine or chloroquine drug regimens (with or without a macrolide) in hospitalised patients with COVID-19.
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Re: Malaria & Covid-19

Post by puku »

JM2K6 wrote:Huge study on Hydroxychloroquine in the lancet
Findings
96 032 patients (mean age 53·8 years, 46·3% women) with COVID-19 were hospitalised during the study period and met the inclusion criteria. Of these, 14 888 patients were in the treatment groups (1868 received chloroquine, 3783 received chloroquine with a macrolide, 3016 received hydroxychloroquine, and 6221 received hydroxychloroquine with a macrolide) and 81 144 patients were in the control group. 10 698 (11·1%) patients died in hospital. After controlling for multiple confounding factors (age, sex, race or ethnicity, body-mass index, underlying cardiovascular disease and its risk factors, diabetes, underlying lung disease, smoking, immunosuppressed condition, and baseline disease severity), when compared with mortality in the control group (9·3%), hydroxychloroquine (18·0%; hazard ratio 1·335, 95% CI 1·223–1·457), hydroxychloroquine with a macrolide (23·8%; 1·447, 1·368–1·531), chloroquine (16·4%; 1·365, 1·218–1·531), and chloroquine with a macrolide (22·2%; 1·368, 1·273–1·469) were each independently associated with an increased risk of in-hospital mortality. Compared with the control group (0·3%), hydroxychloroquine (6·1%; 2·369, 1·935–2·900), hydroxychloroquine with a macrolide (8·1%; 5·106, 4·106–5·983), chloroquine (4·3%; 3·561, 2·760–4·596), and chloroquine with a macrolide (6·5%; 4·011, 3·344–4·812) were independently associated with an increased risk of de-novo ventricular arrhythmia during hospitalisation.
Interpretation
We were unable to confirm a benefit of hydroxychloroquine or chloroquine, when used alone or with a macrolide, on in-hospital outcomes for COVID-19. Each of these drug regimens was associated with decreased in-hospital survival and an increased frequency of ventricular arrhythmias when used for treatment of COVID-19.
So: It doesn't help, and it increases your chance of dying in hospital
Just for the benefit of BillW, azithromycin is a macrolide
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Re: Malaria & Covid-19

Post by JM2K6 »

Laurent wrote:For our FA

https://www.thelancet.com/journals/lanc ... 6/fulltext
Research in context
Evidence before this study
We searched MEDLINE (via PubMed) for articles published up to April 21, 2020, using the key words “novel coronavirus”, “2019-nCoV”, “COVID-19”, “SARS-CoV-2”, “therapy”, “hydroxychloroquine”, “chloroquine”, and “macrolide”. Moreover, we screened preprint servers, such as Medrxiv, for relevant articles and consulted the web pages of organisations such as the US National Institutes of Health and WHO. Hydroxychloroquine and chloroquine (used with or without a macrolide) are widely advocated for treatment of COVID-19 based on in-vitro evidence of an antiviral effect against severe acute respiratory syndrome coronavirus 2. Their use is based on small uncontrolled studies and in the absence of evidence from randomised controlled trials. Concerns have been raised that these drugs or their combination with macrolides could result in electrical instability and predispose patients to ventricular arrhythmias. Whether these drugs improve outcomes or are associated with harm in COVID-19 remains unknown.
Added value of this study
In the absence of reported randomised trials, there is an urgent need to evaluate real-world evidence related to outcomes with the use of hydroxychloroquine or chloroquine (used with or without macrolides) in COVID-19. Using an international, observational registry across six continents, we assessed 96 032 patients with COVID-19, of whom 14 888 were treated with hydroxychloroquine, chloroquine, or their combination with a macrolide. After controlling for age, sex, race or ethnicity, underlying comorbidities, and disease severity at baseline, the use of all four regimens was associated with an increased hazard for de-novo ventricular arrythmia and death in hospital. This study provides real-world evidence on the use of these therapeutic regimens by including a large number of patients from across the world. Thus, to our knowledge, these findings provide the most comprehensive evidence of the use of hydroxychloroquine and chloroquine (with or without a macrolide) for treatment of COVID-19.
Implications of all the available evidence
We found no evidence of benefit of hydroxychloroquine or chloroquine when used either alone or with a macrolide. Previous evidence was derived from either small anecdotal studies or inconclusive small randomised trials. Our study included a large number of patients across multiple geographic regions and provides the most robust real-world evidence to date on the usefulness of these treatment regimens. Although observational studies cannot fully account for unmeasured confounding factors, our findings suggest not only an absence of therapeutic benefit but also potential harm with the use of hydroxychloroquine or chloroquine drug regimens (with or without a macrolide) in hospitalised patients with COVID-19.
Why do you have me on ignore
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Re: Malaria & Covid-19

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Fat Albert wrote:
Both chloroquine and hydroxychloroquine appear to be zinc ionophores. It is the zinc that interferes with a virus. The Corona Virus is an RNA virus. When a virus goes into the cytosol, the ribosomes which read the code of the mRNA can’t tell the difference between the virus RNA and cellular RNA. So, as the ribosomes read the viral RNA they make an RNA dependent RNA polymerase (Replicase) that replicates the viral RNA. It’s a nasty son of a bitch. Zn(2+) will interfere with Replicase. However, zinc doesn’t readily transport inside the cell but, a zinc ionophore helps zinc move inside the cell.
https://youtu.be/NpnEiOOfu1Q
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Re: Malaria & Covid-19

Post by Laurent »

JM2K6 wrote:
Laurent wrote:For our FA

https://www.thelancet.com/journals/lanc ... 6/fulltext
Research in context
Evidence before this study
We searched MEDLINE (via PubMed) for articles published up to April 21, 2020, using the key words “novel coronavirus”, “2019-nCoV”, “COVID-19”, “SARS-CoV-2”, “therapy”, “hydroxychloroquine”, “chloroquine”, and “macrolide”. Moreover, we screened preprint servers, such as Medrxiv, for relevant articles and consulted the web pages of organisations such as the US National Institutes of Health and WHO. Hydroxychloroquine and chloroquine (used with or without a macrolide) are widely advocated for treatment of COVID-19 based on in-vitro evidence of an antiviral effect against severe acute respiratory syndrome coronavirus 2. Their use is based on small uncontrolled studies and in the absence of evidence from randomised controlled trials. Concerns have been raised that these drugs or their combination with macrolides could result in electrical instability and predispose patients to ventricular arrhythmias. Whether these drugs improve outcomes or are associated with harm in COVID-19 remains unknown.
Added value of this study
In the absence of reported randomised trials, there is an urgent need to evaluate real-world evidence related to outcomes with the use of hydroxychloroquine or chloroquine (used with or without macrolides) in COVID-19. Using an international, observational registry across six continents, we assessed 96 032 patients with COVID-19, of whom 14 888 were treated with hydroxychloroquine, chloroquine, or their combination with a macrolide. After controlling for age, sex, race or ethnicity, underlying comorbidities, and disease severity at baseline, the use of all four regimens was associated with an increased hazard for de-novo ventricular arrythmia and death in hospital. This study provides real-world evidence on the use of these therapeutic regimens by including a large number of patients from across the world. Thus, to our knowledge, these findings provide the most comprehensive evidence of the use of hydroxychloroquine and chloroquine (with or without a macrolide) for treatment of COVID-19.
Implications of all the available evidence
We found no evidence of benefit of hydroxychloroquine or chloroquine when used either alone or with a macrolide. Previous evidence was derived from either small anecdotal studies or inconclusive small randomised trials. Our study included a large number of patients across multiple geographic regions and provides the most robust real-world evidence to date on the usefulness of these treatment regimens. Although observational studies cannot fully account for unmeasured confounding factors, our findings suggest not only an absence of therapeutic benefit but also potential harm with the use of hydroxychloroquine or chloroquine drug regimens (with or without a macrolide) in hospitalised patients with COVID-19.
Why do you have me on ignore
You are annoying :P
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JM2K6
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Re: Malaria & Covid-19

Post by JM2K6 »

Yes, but you make identical posts to me so the joke's on you
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Re: Malaria & Covid-19

Post by Laurent »

JM2K6 wrote:Yes, but you make identical posts to me so the joke's on you
Told you you were annoying.
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Re: Malaria & Covid-19

Post by 6.Jones »

Laurent wrote:
JM2K6 wrote:Yes, but you make identical posts to me so the joke's on you
Told you you were annoying.
:lol: quality banter.
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Re: Malaria & Covid-19

Post by Big Nipper »

Where is Fat Albert?
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Re: Malaria & Covid-19

Post by Biffer29 »

Big Nipper wrote:Where is Fat Albert?
Heart attack brought on by Hydroxychloroquine
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Re: Malaria & Covid-19

Post by Uncle Fester »

Big Nipper wrote:Where is Fat Albert?
Seems that he's not too happy with the answers presenting to his "just asking questions" approach.
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Re: Malaria & Covid-19

Post by Yer Man »

Mr Mike wrote:
chloroquine also has strong potential as a prophylactic (preventative) measure against Coronavirus
One would hope so because those maps suggest it is pretty shitty at preventing malaria.
:lol: :lol: :lol: :lol:

Sorry, made me laugh more than perhaps it should have done :blush: :blush:
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Re: Malaria & Covid-19

Post by JM2K6 »

Big news - study retracted!

https://www.thelancet.com/lancet/articl ... 3620313246

Some serious questions to answer here for both the Lancet and the authors - and potentially the reviewers, too. It should be said that despite this, there's still no reputable studies showing this drug to be genuinely useful.

But for a different drug:

https://www.theguardian.com/world/2020/ ... -australia
The preliminary data published so far from two clinical trials indicate that it can reduce the time for someone to recover from Covid-19.
Some good news at least.
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Re: Malaria & Covid-19

Post by message #2527204 »

JM2K6 wrote:Big news - study retracted!

https://www.thelancet.com/lancet/articl ... 3620313246

Some serious questions to answer here for both the Lancet and the authors - and potentially the reviewers, too. It should be said that despite this, there's still no reputable studies showing this drug to be genuinely useful.

But for a different drug:

https://www.theguardian.com/world/2020/ ... -australia
The preliminary data published so far from two clinical trials indicate that it can reduce the time for someone to recover from Covid-19.
Some good news at least.
But WHO halted all hydroxychloroquine studies based on the surgisphere data and this paper.
The Surgisphere database is the issue.
The Peruvian government apparently advised a drug as treatment based on the another paper fromt he same author.

Seems the guy may be a fraud, and a dangerous one at that.

https://www.theguardian.com/world/2020/ ... aincontent
bimboman
Posts: 70038
Joined: Tue Jan 31, 2012 11:05 am

Re: Malaria & Covid-19

Post by bimboman »

JM2K6 wrote:
Laurent wrote:For our FA

https://www.thelancet.com/journals/lanc ... 6/fulltext
Research in context
Evidence before this study
We searched MEDLINE (via PubMed) for articles published up to April 21, 2020, using the key words “novel coronavirus”, “2019-nCoV”, “COVID-19”, “SARS-CoV-2”, “therapy”, “hydroxychloroquine”, “chloroquine”, and “macrolide”. Moreover, we screened preprint servers, such as Medrxiv, for relevant articles and consulted the web pages of organisations such as the US National Institutes of Health and WHO. Hydroxychloroquine and chloroquine (used with or without a macrolide) are widely advocated for treatment of COVID-19 based on in-vitro evidence of an antiviral effect against severe acute respiratory syndrome coronavirus 2. Their use is based on small uncontrolled studies and in the absence of evidence from randomised controlled trials. Concerns have been raised that these drugs or their combination with macrolides could result in electrical instability and predispose patients to ventricular arrhythmias. Whether these drugs improve outcomes or are associated with harm in COVID-19 remains unknown.
Added value of this study
In the absence of reported randomised trials, there is an urgent need to evaluate real-world evidence related to outcomes with the use of hydroxychloroquine or chloroquine (used with or without macrolides) in COVID-19. Using an international, observational registry across six continents, we assessed 96 032 patients with COVID-19, of whom 14 888 were treated with hydroxychloroquine, chloroquine, or their combination with a macrolide. After controlling for age, sex, race or ethnicity, underlying comorbidities, and disease severity at baseline, the use of all four regimens was associated with an increased hazard for de-novo ventricular arrythmia and death in hospital. This study provides real-world evidence on the use of these therapeutic regimens by including a large number of patients from across the world. Thus, to our knowledge, these findings provide the most comprehensive evidence of the use of hydroxychloroquine and chloroquine (with or without a macrolide) for treatment of COVID-19.
Implications of all the available evidence
We found no evidence of benefit of hydroxychloroquine or chloroquine when used either alone or with a macrolide. Previous evidence was derived from either small anecdotal studies or inconclusive small randomised trials. Our study included a large number of patients across multiple geographic regions and provides the most robust real-world evidence to date on the usefulness of these treatment regimens. Although observational studies cannot fully account for unmeasured confounding factors, our findings suggest not only an absence of therapeutic benefit but also potential harm with the use of hydroxychloroquine or chloroquine drug regimens (with or without a macrolide) in hospitalised patients with COVID-19.
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JM2K6
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Re: Malaria & Covid-19

Post by JM2K6 »

message #2527204 wrote:
JM2K6 wrote:Big news - study retracted!

https://www.thelancet.com/lancet/articl ... 3620313246

Some serious questions to answer here for both the Lancet and the authors - and potentially the reviewers, too. It should be said that despite this, there's still no reputable studies showing this drug to be genuinely useful.

But for a different drug:

https://www.theguardian.com/world/2020/ ... -australia
The preliminary data published so far from two clinical trials indicate that it can reduce the time for someone to recover from Covid-19.
Some good news at least.
But WHO halted all hydroxychloroquine studies based on the surgisphere data and this paper.
The Surgisphere database is the issue.
The Peruvian government apparently advised a drug as treatment based on the another paper fromt he same author.

Seems the guy may be a fraud, and a dangerous one at that.

https://www.theguardian.com/world/2020/ ... aincontent
It's not just the WHO doing studies and clinical trials on the drug. There's 50+ in the US alone.

e.g. https://www.nejm.org/doi/full/10.1056/NEJMoa2012410
Biffer29
Posts: 1865
Joined: Fri Mar 09, 2018 11:18 pm

Re: Malaria & Covid-19

Post by Biffer29 »

Having been hugely sceptical of hydroxychloroquine initially (because I thought the likelihood of something to treat a blood borne parasitical illness having an effect on a respiratory disease was a bit of a reach), some of the more recent information on the effects of COVID19 have, to me, given some kind of connection of why it might be effective. It's becoming more evident that CV19 is at least in part a blood disease (which makes it incredibly unusual, a respiratory infection which goes on to act on the blood) which is causing severe clotting in some patients. This might tie together a lot of the more weird symptoms - seizures, heart attacks, aneurysms as well as the severe inflammation of the lungs. It might also help to explain why diabetics and those with high blood pressure seem to be more in danger from the disease. Given that malaria is a blood disease, and that HC (from my very limited reading and understanding) works at least partly as an anti-inflammatory, although the full action of it isn't fully understood, you can start to see a pathway where it may have an effect. However, what it might indicate more than anything else is a route to effective treatment through existing drugs for blood diseases, some of which might be more beneficial or have fewer potential side effects. I've seen some other reports that patients already on drugs to prevent blood clots seem to have lower rates of serious illness.
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