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 Post subject: Re: Malaria & Covid-19
PostPosted: Tue Mar 31, 2020 3:26 pm 
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Dr. Vladimir Zelenko has now treated 699 coronavirus patients with 100% success using Hydroxychloroquine Sulfate, Zinc and Z-Pak
Quote:
Dr. Zelenko provides updates after he successfully treated 699 COVID-19 patients in New York. In an exclusive interview with former New York Mayor, Rudy Giuliani, Dr. Vladmir Zelenko shares the results of his latest study, which showed that out of his 699 patients treated, zero patients died, zero patients intubated, and four hospitalizations.

French researchers completed additional study on 80 patients, results show a combination of Hydroxychloroquine and Azithromycin to be effective in treating COVID-19
Quote:
We need an effective treatment to cure COVID-19 patients and to decrease the virus carriage duration. In 80 in-patients receiving a combination of hydroxychloroquine and azithromycin we noted a clinical improvement in all but one 86 year-old patient who died, and one 74 yearold patient still in intensive care unit. A rapid fall of nasopharyngeal viral load tested by qPCR was noted, with 83% negative at Day7, and 93% at Day8. Virus cultures from patient respiratory samples were negative in 97.5% patients at Day5. This allowed patients to rapidly be discharge from highly contagious wards with a mean length of stay of five days. We believe other teams should urgently evaluate this cost-effective therapeutic strategy, to both avoid the spread of the disease and treat patients as soon as possible before severe respiratory irreversible complications take hold.


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 Post subject: Re: Malaria & Covid-19
PostPosted: Tue Mar 31, 2020 3:27 pm 
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msp. wrote:
How many of the population in places that have Malaria are on these drugs, most of the population cannot afford to be in anti-malaria drugs, it is mainly westerners going to those locations that take the drugs.

The protection that most have is sleeping under a net, (could it be this that is providing the protection).

Don't tell Trump.


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 Post subject: Re: Malaria & Covid-19
PostPosted: Tue Mar 31, 2020 3:39 pm 
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In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
Quote:
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) first broke out in Wuhan (China) and subsequently spread worldwide. Chloroquine has been sporadically used in treating SARS-CoV-2 infection. Hydroxychloroquine shares the same mechanism of action as chloroquine, but its more tolerable safety profile makes it the preferred drug to treat malaria and autoimmune conditions. We propose that the immunomodulatory effect of hydroxychloroquine also may be useful in controlling the cytokine storm that occurs late-phase in critically ill SARS-CoV-2 infected patients. Currently, there is no evidence to support the use of hydroxychloroquine in SARS-CoV-2 infection.
Yes, I noted the last sentence, which refers to evidence 'in vitro' (laboratory), the paper does not refer to efficacy on patients.

Surely there is now more than enough practical evidence, with more published every day, that Hydroxychloroquin though not a panacea, is of net benefit to Covid-19 patients.


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 Post subject: Re: Malaria & Covid-19
PostPosted: Tue Mar 31, 2020 3:42 pm 
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Fat Albert wrote:
Dr. Vladimir Zelenko has now treated 699 coronavirus patients with 100% success using Hydroxychloroquine Sulfate, Zinc and Z-Pak
Quote:
Dr. Zelenko provides updates after he successfully treated 699 COVID-19 patients in New York. In an exclusive interview with former New York Mayor, Rudy Giuliani, Dr. Vladmir Zelenko shares the results of his latest study, which showed that out of his 699 patients treated, zero patients died, zero patients intubated, and four hospitalizations.


A massive pinch of salt required.

https://www.snopes.com/fact-check/zelen ... -patients/

"Zelenko’s claims, however, rest solely on taking him at his word: He has published no data, described no study design, and reported no analysis."


Quote:
French researchers completed additional study on 80 patients, results show a combination of Hydroxychloroquine and Azithromycin to be effective in treating COVID-19
Quote:
We need an effective treatment to cure COVID-19 patients and to decrease the virus carriage duration. In 80 in-patients receiving a combination of hydroxychloroquine and azithromycin we noted a clinical improvement in all but one 86 year-old patient who died, and one 74 yearold patient still in intensive care unit. A rapid fall of nasopharyngeal viral load tested by qPCR was noted, with 83% negative at Day7, and 93% at Day8. Virus cultures from patient respiratory samples were negative in 97.5% patients at Day5. This allowed patients to rapidly be discharge from highly contagious wards with a mean length of stay of five days. We believe other teams should urgently evaluate this cost-effective therapeutic strategy, to both avoid the spread of the disease and treat patients as soon as possible before severe respiratory irreversible complications take hold.


This is much more promising :thumbup: and is one of the main reasons why this treatment is being talked about (though with this caveat https://www.france24.com/en/20200331-fr ... treatments ). However, this study has no control group, which makes it a very hard sell indeed. I thoroughly recommend reading the comments here: https://pubpeer.com/publications/16FA31 ... E929C86BB0

Note that their previous publications were really rushed and they never responded to peer review & criticism, so again, pinch of salt.

Would be brilliant if it was true, though (and that easy).


More reading on that study:

https://sciencebasedmedicine.org/hydrox ... -covid-19/
https://blogs.sciencemag.org/pipeline/a ... -dr-raoult


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 Post subject: Re: Malaria & Covid-19
PostPosted: Tue Mar 31, 2020 4:15 pm 
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Derwyn wrote:
Fat Albert wrote:
Quote:
Both chloroquine and hydroxychloroquine appear to be zinc ionophores. It is the zinc that interferes with a virus. The Corona Virus is an RNA virus. When a virus goes into the cytosol, the ribosomes which read the code of the mRNA can’t tell the difference between the virus RNA and cellular RNA. So, as the ribosomes read the viral RNA they make an RNA dependent RNA polymerase (Replicase) that replicates the viral RNA. It’s a nasty son of a bitch. Zn(2+) will interfere with Replicase. However, zinc doesn’t readily transport inside the cell but, a zinc ionophore helps zinc move inside the cell.

Just what I was going to say.

I read Quercetin is a zinc ionophore.


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 Post subject: Re: Malaria & Covid-19
PostPosted: Tue Mar 31, 2020 4:17 pm 
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JM2K6 wrote:
However, this study has no control group, which makes it a very hard sell indeed.
I can just imagine the response of the relatives of those desperately ill patients who are told that they are going to be part of a double blind trial where some will receive a placebo...

Again, I'm glad I'm not a doctor/administrator making those decisions...


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 Post subject: Re: Malaria & Covid-19
PostPosted: Tue Mar 31, 2020 4:24 pm 
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Fat Albert wrote:
JM2K6 wrote:
However, this study has no control group, which makes it a very hard sell indeed.
I can just imagine the response of the relatives of those desperately ill patients who are told that they are going to be part of a double blind trial where some will receive a placebo...

Again, I'm glad I'm not a doctor/administrator making those decisions...


Sure - but science is science. It's also not obvious they were desperately ill; only 15% had a fever, four of them didn't have any symptoms at all (!?!).

The more I read about that study, the worse it gets. Right from the start (calling it an observational study when it clearly isn't, seemingly to avoid certain restrictions) there's red flags and the responses I've posted seem to be pretty clear that this work is incredibly dubious.

We need good science now more than ever. It's not clear that this is good science.


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 Post subject: Re: Malaria & Covid-19
PostPosted: Tue Mar 31, 2020 4:32 pm 
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Fat Albert wrote:
Dr. Vladimir Zelenko has now treated 699 coronavirus patients with 100% success using Hydroxychloroquine Sulfate, Zinc and Z-Pak
Quote:
Dr. Zelenko provides updates after he successfully treated 699 COVID-19 patients in New York. In an exclusive interview with former New York Mayor, Rudy Giuliani, Dr. Vladmir Zelenko shares the results of his latest study, which showed that out of his 699 patients treated, zero patients died, zero patients intubated, and four hospitalizations.


Why am I not surprised that Mad Rudy is balls deep in this.

A proper trial at my place of work.


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 Post subject: Re: Malaria & Covid-19
PostPosted: Tue Mar 31, 2020 4:45 pm 
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puku wrote:
Fat Albert wrote:
Dr. Vladimir Zelenko has now treated 699 coronavirus patients with 100% success using Hydroxychloroquine Sulfate, Zinc and Z-Pak
Quote:
Dr. Zelenko provides updates after he successfully treated 699 COVID-19 patients in New York. In an exclusive interview with former New York Mayor, Rudy Giuliani, Dr. Vladmir Zelenko shares the results of his latest study, which showed that out of his 699 patients treated, zero patients died, zero patients intubated, and four hospitalizations.


Why am I not surprised that Mad Rudy is balls deep in this.

A proper trial at my place of work.

Good stuff. Sounds as though FA knows a hospital in the UK where they are possibly running trials too.


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 Post subject: Re: Malaria & Covid-19
PostPosted: Tue Mar 31, 2020 5:43 pm 
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Saw on twitter that some tweets highlighting successful uses of chloroquine were being removed x(


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 Post subject: Re: Malaria & Covid-19
PostPosted: Tue Mar 31, 2020 6:52 pm 
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Lemoentjie wrote:
Saw on twitter that some tweets highlighting successful uses of chloroquine were being removed x(

Probably regarded as fake/dangerous news.
Enough people died in Iran for stuff like that to be taken down.


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 Post subject: Re: Malaria & Covid-19
PostPosted: Tue Mar 31, 2020 7:29 pm 
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Lemoentjie wrote:
Saw on twitter that some tweets highlighting successful uses of chloroquine were being removed x(


Twitter and Facebook are pulling down stories regarding any treatment not on the WHO list. So far Donald's comments are staying up but that won't last


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 Post subject: Re: Malaria & Covid-19
PostPosted: Wed Apr 01, 2020 3:26 am 
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Rugby2023 wrote:
Derwyn wrote:
Fat Albert wrote:
Quote:
Both chloroquine and hydroxychloroquine appear to be zinc ionophores. It is the zinc that interferes with a virus. The Corona Virus is an RNA virus. When a virus goes into the cytosol, the ribosomes which read the code of the mRNA can’t tell the difference between the virus RNA and cellular RNA. So, as the ribosomes read the viral RNA they make an RNA dependent RNA polymerase (Replicase) that replicates the viral RNA. It’s a nasty son of a bitch. Zn(2+) will interfere with Replicase. However, zinc doesn’t readily transport inside the cell but, a zinc ionophore helps zinc move inside the cell.

Just what I was going to say.

I read Quercetin is a zinc ionophore.




This from the internet, dates back to 2010. Apparently peer reviewed.

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1001176


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 Post subject: Re: Malaria & Covid-19
PostPosted: Wed Apr 01, 2020 9:07 am 
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Hydroxychloroquine and azithromycin are both QT prolongation drugs meaning both, especially if used in combination, can cause ventricular arrhythmia and may very well kill an elderly person with existing VA. Both are also associated with liver failure in the hepatically impaired.


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 Post subject: Re: Malaria & Covid-19
PostPosted: Wed Apr 01, 2020 9:11 am 
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Hellraiser wrote:
Hydroxychloroquine and azithromycin are both QT prolongation drugs meaning both, especially if used in combination, can cause ventricular arrhythmia and may very well kill an elderly person with existing VA. Both are also associated with liver failure in the hepatically impaired.

Yeah. But Trump has a hunch.


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 Post subject: Re: Malaria & Covid-19
PostPosted: Wed Apr 01, 2020 9:26 pm 
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Hellraiser wrote:
Hydroxychloroquine and azithromycin are both QT prolongation drugs meaning both, especially if used in combination, can cause ventricular arrhythmia and may very well kill an elderly person with existing VA. Both are also associated with liver failure in the hepatically impaired.

known side effects, and why zelenko starts with low doses.

when the odds of dying are worse without treatment you'll take the chance.


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 Post subject: Re: Malaria & Covid-19
PostPosted: Mon Apr 06, 2020 3:03 pm 
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https://twitter.com/DrEricDing/status/1 ... 3468306433

Quote:
Chloroquine #COVID19 trial discontinued in Sweden cuz of severe side effects- seizure and vision problems in patients. (
📍 Early clinical trial termination is strictly guided by data safety monitoring committees- stoppages are rare & big deal bad signs)


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 Post subject: Re: Malaria & Covid-19
PostPosted: Mon Apr 06, 2020 6:02 pm 
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https://blogs.sciencemag.org/pipeline/a ... or-april-6


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 Post subject: Re: Malaria & Covid-19
PostPosted: Fri May 22, 2020 3:25 pm 
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Huge study on Hydroxychloroquine in the lancet

Quote:
Findings
96 032 patients (mean age 53·8 years, 46·3% women) with COVID-19 were hospitalised during the study period and met the inclusion criteria. Of these, 14 888 patients were in the treatment groups (1868 received chloroquine, 3783 received chloroquine with a macrolide, 3016 received hydroxychloroquine, and 6221 received hydroxychloroquine with a macrolide) and 81 144 patients were in the control group. 10 698 (11·1%) patients died in hospital. After controlling for multiple confounding factors (age, sex, race or ethnicity, body-mass index, underlying cardiovascular disease and its risk factors, diabetes, underlying lung disease, smoking, immunosuppressed condition, and baseline disease severity), when compared with mortality in the control group (9·3%), hydroxychloroquine (18·0%; hazard ratio 1·335, 95% CI 1·223–1·457), hydroxychloroquine with a macrolide (23·8%; 1·447, 1·368–1·531), chloroquine (16·4%; 1·365, 1·218–1·531), and chloroquine with a macrolide (22·2%; 1·368, 1·273–1·469) were each independently associated with an increased risk of in-hospital mortality. Compared with the control group (0·3%), hydroxychloroquine (6·1%; 2·369, 1·935–2·900), hydroxychloroquine with a macrolide (8·1%; 5·106, 4·106–5·983), chloroquine (4·3%; 3·561, 2·760–4·596), and chloroquine with a macrolide (6·5%; 4·011, 3·344–4·812) were independently associated with an increased risk of de-novo ventricular arrhythmia during hospitalisation.
Interpretation
We were unable to confirm a benefit of hydroxychloroquine or chloroquine, when used alone or with a macrolide, on in-hospital outcomes for COVID-19. Each of these drug regimens was associated with decreased in-hospital survival and an increased frequency of ventricular arrhythmias when used for treatment of COVID-19.


So: It doesn't help, and it increases your chance of dying in hospital


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 Post subject: Re: Malaria & Covid-19
PostPosted: Fri May 22, 2020 3:41 pm 
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Yeah but it's acts with covid-19 like garlic does with vampires


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 Post subject: Re: Malaria & Covid-19
PostPosted: Fri May 22, 2020 4:02 pm 
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. But he still has a hunch, and 100m doses. Got to find s market for that stuff.

Trump's genuine hydroxysnakeoiline cures aids, covid, cancer and erectile dysfunction.


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 Post subject: Re: Malaria & Covid-19
PostPosted: Fri May 22, 2020 8:43 pm 
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For our FA

https://www.thelancet.com/journals/lanc ... 40-6736(20)31180-6/fulltext

Quote:
Research in context
Evidence before this study
We searched MEDLINE (via PubMed) for articles published up to April 21, 2020, using the key words “novel coronavirus”, “2019-nCoV”, “COVID-19”, “SARS-CoV-2”, “therapy”, “hydroxychloroquine”, “chloroquine”, and “macrolide”. Moreover, we screened preprint servers, such as Medrxiv, for relevant articles and consulted the web pages of organisations such as the US National Institutes of Health and WHO. Hydroxychloroquine and chloroquine (used with or without a macrolide) are widely advocated for treatment of COVID-19 based on in-vitro evidence of an antiviral effect against severe acute respiratory syndrome coronavirus 2. Their use is based on small uncontrolled studies and in the absence of evidence from randomised controlled trials. Concerns have been raised that these drugs or their combination with macrolides could result in electrical instability and predispose patients to ventricular arrhythmias. Whether these drugs improve outcomes or are associated with harm in COVID-19 remains unknown.
Added value of this study
In the absence of reported randomised trials, there is an urgent need to evaluate real-world evidence related to outcomes with the use of hydroxychloroquine or chloroquine (used with or without macrolides) in COVID-19. Using an international, observational registry across six continents, we assessed 96 032 patients with COVID-19, of whom 14 888 were treated with hydroxychloroquine, chloroquine, or their combination with a macrolide. After controlling for age, sex, race or ethnicity, underlying comorbidities, and disease severity at baseline, the use of all four regimens was associated with an increased hazard for de-novo ventricular arrythmia and death in hospital. This study provides real-world evidence on the use of these therapeutic regimens by including a large number of patients from across the world. Thus, to our knowledge, these findings provide the most comprehensive evidence of the use of hydroxychloroquine and chloroquine (with or without a macrolide) for treatment of COVID-19.
Implications of all the available evidence
We found no evidence of benefit of hydroxychloroquine or chloroquine when used either alone or with a macrolide. Previous evidence was derived from either small anecdotal studies or inconclusive small randomised trials. Our study included a large number of patients across multiple geographic regions and provides the most robust real-world evidence to date on the usefulness of these treatment regimens. Although observational studies cannot fully account for unmeasured confounding factors, our findings suggest not only an absence of therapeutic benefit but also potential harm with the use of hydroxychloroquine or chloroquine drug regimens (with or without a macrolide) in hospitalised patients with COVID-19.


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 Post subject: Re: Malaria & Covid-19
PostPosted: Fri May 22, 2020 9:12 pm 
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JM2K6 wrote:
Huge study on Hydroxychloroquine in the lancet

Quote:
Findings
96 032 patients (mean age 53·8 years, 46·3% women) with COVID-19 were hospitalised during the study period and met the inclusion criteria. Of these, 14 888 patients were in the treatment groups (1868 received chloroquine, 3783 received chloroquine with a macrolide, 3016 received hydroxychloroquine, and 6221 received hydroxychloroquine with a macrolide) and 81 144 patients were in the control group. 10 698 (11·1%) patients died in hospital. After controlling for multiple confounding factors (age, sex, race or ethnicity, body-mass index, underlying cardiovascular disease and its risk factors, diabetes, underlying lung disease, smoking, immunosuppressed condition, and baseline disease severity), when compared with mortality in the control group (9·3%), hydroxychloroquine (18·0%; hazard ratio 1·335, 95% CI 1·223–1·457), hydroxychloroquine with a macrolide (23·8%; 1·447, 1·368–1·531), chloroquine (16·4%; 1·365, 1·218–1·531), and chloroquine with a macrolide (22·2%; 1·368, 1·273–1·469) were each independently associated with an increased risk of in-hospital mortality. Compared with the control group (0·3%), hydroxychloroquine (6·1%; 2·369, 1·935–2·900), hydroxychloroquine with a macrolide (8·1%; 5·106, 4·106–5·983), chloroquine (4·3%; 3·561, 2·760–4·596), and chloroquine with a macrolide (6·5%; 4·011, 3·344–4·812) were independently associated with an increased risk of de-novo ventricular arrhythmia during hospitalisation.
Interpretation
We were unable to confirm a benefit of hydroxychloroquine or chloroquine, when used alone or with a macrolide, on in-hospital outcomes for COVID-19. Each of these drug regimens was associated with decreased in-hospital survival and an increased frequency of ventricular arrhythmias when used for treatment of COVID-19.


So: It doesn't help, and it increases your chance of dying in hospital


Just for the benefit of BillW, azithromycin is a macrolide


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 Post subject: Re: Malaria & Covid-19
PostPosted: Fri May 22, 2020 10:59 pm 
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Laurent wrote:
For our FA

https://www.thelancet.com/journals/lanc ... 40-6736(20)31180-6/fulltext

Quote:
Research in context
Evidence before this study
We searched MEDLINE (via PubMed) for articles published up to April 21, 2020, using the key words “novel coronavirus”, “2019-nCoV”, “COVID-19”, “SARS-CoV-2”, “therapy”, “hydroxychloroquine”, “chloroquine”, and “macrolide”. Moreover, we screened preprint servers, such as Medrxiv, for relevant articles and consulted the web pages of organisations such as the US National Institutes of Health and WHO. Hydroxychloroquine and chloroquine (used with or without a macrolide) are widely advocated for treatment of COVID-19 based on in-vitro evidence of an antiviral effect against severe acute respiratory syndrome coronavirus 2. Their use is based on small uncontrolled studies and in the absence of evidence from randomised controlled trials. Concerns have been raised that these drugs or their combination with macrolides could result in electrical instability and predispose patients to ventricular arrhythmias. Whether these drugs improve outcomes or are associated with harm in COVID-19 remains unknown.
Added value of this study
In the absence of reported randomised trials, there is an urgent need to evaluate real-world evidence related to outcomes with the use of hydroxychloroquine or chloroquine (used with or without macrolides) in COVID-19. Using an international, observational registry across six continents, we assessed 96 032 patients with COVID-19, of whom 14 888 were treated with hydroxychloroquine, chloroquine, or their combination with a macrolide. After controlling for age, sex, race or ethnicity, underlying comorbidities, and disease severity at baseline, the use of all four regimens was associated with an increased hazard for de-novo ventricular arrythmia and death in hospital. This study provides real-world evidence on the use of these therapeutic regimens by including a large number of patients from across the world. Thus, to our knowledge, these findings provide the most comprehensive evidence of the use of hydroxychloroquine and chloroquine (with or without a macrolide) for treatment of COVID-19.
Implications of all the available evidence
We found no evidence of benefit of hydroxychloroquine or chloroquine when used either alone or with a macrolide. Previous evidence was derived from either small anecdotal studies or inconclusive small randomised trials. Our study included a large number of patients across multiple geographic regions and provides the most robust real-world evidence to date on the usefulness of these treatment regimens. Although observational studies cannot fully account for unmeasured confounding factors, our findings suggest not only an absence of therapeutic benefit but also potential harm with the use of hydroxychloroquine or chloroquine drug regimens (with or without a macrolide) in hospitalised patients with COVID-19.


Why do you have me on ignore


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 Post subject: Re: Malaria & Covid-19
PostPosted: Fri May 22, 2020 11:40 pm 
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Fat Albert wrote:
Quote:
Both chloroquine and hydroxychloroquine appear to be zinc ionophores. It is the zinc that interferes with a virus. The Corona Virus is an RNA virus. When a virus goes into the cytosol, the ribosomes which read the code of the mRNA can’t tell the difference between the virus RNA and cellular RNA. So, as the ribosomes read the viral RNA they make an RNA dependent RNA polymerase (Replicase) that replicates the viral RNA. It’s a nasty son of a bitch. Zn(2+) will interfere with Replicase. However, zinc doesn’t readily transport inside the cell but, a zinc ionophore helps zinc move inside the cell.

https://youtu.be/NpnEiOOfu1Q


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 Post subject: Re: Malaria & Covid-19
PostPosted: Sat May 23, 2020 7:02 am 
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JM2K6 wrote:
Laurent wrote:
For our FA

https://www.thelancet.com/journals/lanc ... 40-6736(20)31180-6/fulltext

Quote:
Research in context
Evidence before this study
We searched MEDLINE (via PubMed) for articles published up to April 21, 2020, using the key words “novel coronavirus”, “2019-nCoV”, “COVID-19”, “SARS-CoV-2”, “therapy”, “hydroxychloroquine”, “chloroquine”, and “macrolide”. Moreover, we screened preprint servers, such as Medrxiv, for relevant articles and consulted the web pages of organisations such as the US National Institutes of Health and WHO. Hydroxychloroquine and chloroquine (used with or without a macrolide) are widely advocated for treatment of COVID-19 based on in-vitro evidence of an antiviral effect against severe acute respiratory syndrome coronavirus 2. Their use is based on small uncontrolled studies and in the absence of evidence from randomised controlled trials. Concerns have been raised that these drugs or their combination with macrolides could result in electrical instability and predispose patients to ventricular arrhythmias. Whether these drugs improve outcomes or are associated with harm in COVID-19 remains unknown.
Added value of this study
In the absence of reported randomised trials, there is an urgent need to evaluate real-world evidence related to outcomes with the use of hydroxychloroquine or chloroquine (used with or without macrolides) in COVID-19. Using an international, observational registry across six continents, we assessed 96 032 patients with COVID-19, of whom 14 888 were treated with hydroxychloroquine, chloroquine, or their combination with a macrolide. After controlling for age, sex, race or ethnicity, underlying comorbidities, and disease severity at baseline, the use of all four regimens was associated with an increased hazard for de-novo ventricular arrythmia and death in hospital. This study provides real-world evidence on the use of these therapeutic regimens by including a large number of patients from across the world. Thus, to our knowledge, these findings provide the most comprehensive evidence of the use of hydroxychloroquine and chloroquine (with or without a macrolide) for treatment of COVID-19.
Implications of all the available evidence
We found no evidence of benefit of hydroxychloroquine or chloroquine when used either alone or with a macrolide. Previous evidence was derived from either small anecdotal studies or inconclusive small randomised trials. Our study included a large number of patients across multiple geographic regions and provides the most robust real-world evidence to date on the usefulness of these treatment regimens. Although observational studies cannot fully account for unmeasured confounding factors, our findings suggest not only an absence of therapeutic benefit but also potential harm with the use of hydroxychloroquine or chloroquine drug regimens (with or without a macrolide) in hospitalised patients with COVID-19.


Why do you have me on ignore

You are annoying :P


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 Post subject: Re: Malaria & Covid-19
PostPosted: Sat May 23, 2020 8:16 am 
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Yes, but you make identical posts to me so the joke's on you


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 Post subject: Re: Malaria & Covid-19
PostPosted: Sat May 23, 2020 8:29 am 
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JM2K6 wrote:
Yes, but you make identical posts to me so the joke's on you

Told you you were annoying.


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 Post subject: Re: Malaria & Covid-19
PostPosted: Sat May 23, 2020 8:37 am 
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Laurent wrote:
JM2K6 wrote:
Yes, but you make identical posts to me so the joke's on you

Told you you were annoying.

:lol: quality banter.


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 Post subject: Re: Malaria & Covid-19
PostPosted: Sat May 23, 2020 9:19 am 
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Location: The Fountain of Running Rugby
Where is Fat Albert?


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 Post subject: Re: Malaria & Covid-19
PostPosted: Sat May 23, 2020 9:54 am 
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Big Nipper wrote:
Where is Fat Albert?


Heart attack brought on by Hydroxychloroquine


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 Post subject: Re: Malaria & Covid-19
PostPosted: Mon May 25, 2020 8:07 pm 
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Big Nipper wrote:
Where is Fat Albert?

Seems that he's not too happy with the answers presenting to his "just asking questions" approach.


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 Post subject: Re: Malaria & Covid-19
PostPosted: Mon May 25, 2020 8:29 pm 
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Mr Mike wrote:
Quote:
chloroquine also has strong potential as a prophylactic (preventative) measure against Coronavirus
One would hope so because those maps suggest it is pretty shitty at preventing malaria.

:lol: :lol: :lol: :lol:

Sorry, made me laugh more than perhaps it should have done :blush: :blush:


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